The Diet That Might Cure Depression

Author: Olga Khazan

Several studies show that healthy eating is connected with better mood.

At the turn of the 20th century, prominent physicians who were trying to understand where mental illness comes from seized on a new theory: autointoxication. Intestinal microbes, these doctors suggested, are actually dangerous to their human hosts. They have a way of inducing “fatigue, melancholia, and the neuroses,” as a historical article in the journal Gut Pathogens recounts.

“The control of man’s diet is readily accomplished, but mastery over his intestinal bacterial flora is not,” wrote a doctor named Bond Stow in the Medical Record Journal of Medicine and Surgery in 1914. “The innumerable examples of autointoxication that one sees in his daily walks in life is proof thereof ... malaise, total lack of ambition so that every effort in life is a burden, mental depression often bordering upon melancholia.”

Stow went on to say that “a battle royal must be fought” with these intestinal germs.

Another physician, Daniel R. Brower of Rush Medical College, suspected that the increasing rates of melancholia—depression—in Western society might be the result of changing dietary habits and the resulting toxins dwelling in the gut.

Of course, like most medical ideas at the time, this one was not quite right. (And the proposed cures—removing part of the colon or eating rotten meat—seem worse than the disease.) Your gut doesn’t contain “toxins” that are poisonous so much as it hosts a diverse colony of bacteria called the “microbiome.” But these doctors were right about one thing: What we eat does affect how we feel, and gut microbes likely play a role.

A poor diet is a leading risk factor for early death, responsible for one in five deaths globally. Depression, meanwhile, is the leading cause of disability worldwide. A relatively new line of research suggests the two might be related: An unhealthy diet might make us depressed, and depression, in turn, makes us feel even sicker.

In a one abstract, researchers studying 964 elderly participants over six and a half years found those who followed the DASH diet, which emphasizes whole grains, fruits, and vegetables, had lower rates of depression, while those who ate a traditional Western diet were more prone to depression. The participants were asked how often they ate various foods, and they were screened for depression annually using a questionnaire.

“I think we need to view food as medicine,” Laurel J. Cherian, an assistant professor of vascular neurology at Rush University Medical Center in Chicago and the study’s lead author, told me. “Medications to treat depression are wonderful, but for many people, it’s going to be a combination of things.”
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The research will be presented at the upcoming meeting of the American Academy of Neurology. The study has not been published yet in a peer-reviewed journal, but other researchers have found similar antidepression benefits from the DASH diet, which was developed by the U.S. National Heart, Lung, and Blood Institute.

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